THE NERD’S PAGE

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon

Donohoe, Dallas R., Nikhil Garge, Xinxin Zhang, Wei Sun, Thomas M. O’Connell, Maureen K. Bunger, and Scott J. Bultman. “The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon.” Cell Metabolism 13, no. 5 (2011): 517–26. doi:10.1016/j.cmet.2011.02.018. FULL TEXT »

Keeping bugs in check: The mucus layer as a critical component in maintaining intestinal homeostasis

Faderl, Martin, Mario Noti, Nadia Corazza, and Christoph Mueller. “Keeping Bugs in Check: The Mucus Layer as a Critical Component in Maintaining Intestinal Homeostasis.” IUBMB Life, 2015. doi:10.1002/iub.1374. FULL TEXT »

The composition of the gut microbiota shapes the colon mucus barrier

Jakobsson, Hedvig E, Ana M Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C Hansson, and Malin Ev Johansson. “The Composition of the Gut Microbiota Shapes the Colon Mucus Barrier.” EMBO Reports 16 (2015): 164–77. doi:10.15252/embr. FULL TEXT »

Mucus and the goblet cell

Johansson, Malin E V, and Gunnar C. Hansson. “Mucus and the Goblet Cell.” In Digestive Diseases, 31:305–9, 2013. doi:10.1159/000354683. FULL TEXT »

Prioritization of a plant polysaccharide over a mucus carbohydrate is enforced by a Bacteroides hybrid two-component system

Lynch, Jonathan B., and Justin L. Sonnenburg. “Prioritization of a Plant Polysaccharide over a Mucus Carbohydrate Is Enforced by a Bacteroides Hybrid Two-Component System.” Molecular Microbiology 85, no. 3 (2012): 478–91. doi:10.1111/j.1365-2958.2012.08123.x. FULL TEXT »

Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes

Musso, Giovanni, Roberto Gambino, and Maurizio Cassader. “Interactions between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes.” Annual Review of Medicine 62 (2011): 361–80. doi:10.1146/annurev-med-012510-175505. ABSTRACT »

Glycan foraging in vivo by an intestine-adapted bacterial symbiont

Sonnenburg, Justin L, Jian Xu, Douglas D Leip, Chien-Huan Chen, Benjamin P Westover, Jeremy Weatherford, Jeremy D Buhler, and Jeffrey I Gordon. “Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont.” Science (New York, N.Y.) 307, no. 5717 (2005): 1955–59. doi:10.1126/science.1109051. ABSTRACT »

Fiber’s Cancer-Fighting Effect Depends on Gut Bacteria

by Rachael Rettner FULL TEXT »

Fiber-Famished Gut Microbes Linked to Poor Health

by Katherine Harmon Courage FULL TEXT »

Faecal SigA secretion in infants fed on pre- or probiotic infant formula

Bakker‐Zierikzee, A. M., Tol, V. E., Kroes, H., Alles, M. S., Kok, F. J., & Bindels, J. G. (2006). Faecal SIgA secretion in infants fed on pre‐or probiotic infant formula. Pediatric Allergy and Immunology, 17(2), 134-140. ABSTRACT »

Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial.

E Furrie et al., “Synbiotic Therapy (Bifidobacterium longum/Synergy 1) Initiates Resolution of Inflammation in Patients with Active Ulcerative Colitis: A Randomised Controlled Pilot Trial.,” Gut 54, no. 2 (February 2005): 242–49, doi:10.1136/gut.2004.044834. FULL TEXT »

Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial

Gori, A., Rizzardini, G., Van’t Land, B., Amor, K. B., Van Schaik, J., Torti, C., … & Clerici, M. (2011). Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial. Mucosal immunology, 4(5), 554-563. FULL TEXT »

Effects of Oligosaccharide on the Faecal Flora and Non-Specific Immune System in Elderly People

Y Guigoz et al., “Effects of Oligosaccharide on the Faecal Flora and Non-Specific Immune System in Elderly People,” Nutrition Research 22, no. 1–2 (January 1, 2002): 13–25, doi:10.1016/S0271-5317(01)00354-2. ABSTRACT »

Clinical, microbiological, and immunological effects of fructo‐oligosaccharide in patients with Crohn’s disease

J O Lindsay et al., “Clinical, Microbiological, and Immunological Effects of Fructo-Oligosaccharide in Patients with Crohn’s Disease.,” Gut 55, no. 3 (March 2006): 348–55, doi:10.1136/gut.2005.074971. FULL TEXT »

A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age

G Moro et al., “A Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Atopic Dermatitis during the First Six Months of Age.,” Archives of Disease in Childhood 91, no. 10 (October 2006): 814–19, doi:10.1136/adc.2006.098251. FULL TEXT »

Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients.

Monika Roller et al., “Consumption of Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus Rhamnosus and Bifidobacterium Lactis Has Minor Effects on Selected Immune Parameters in Polypectomised and Colon Cancer Patients.,” The British Journal of Nutrition 97, no. 4 (April 2007): 676–84, doi:10.1017/S0007114507450292. FULL TEXT »

Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics

E J Schiffrin et al., “Systemic Inflammatory Markers in Older Persons: The Effect of Oral Nutritional Supplementation with Prebiotics.,” The Journal of Nutrition, Health & Aging 11, no. 6 (January ): 475–79. ABSTRACT »

Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides.

Petra A M J Scholtens et al., “Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides.,” The Journal of Nutrition 138, no. 6 (June 2008): 1141–47. FULL TEXT »

Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd.

Mayank Thakur et al., “Characterization and in Vitro Immunomodulatory Screening of Fructo-Oligosaccharides of Asparagus Racemosus Willd.,” International Journal of Biological Macromolecules 50, no. 1 (January 1, 2012): 77–81, doi:10.1016/j.ijbiomac.2011.09.027. ABSTRACT »

Short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea.

Nachum Vaisman et al., “Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea.,” Nutrients 2, no. 7 (July 30, 2010): 683–92, doi:10.3390/nu2070683. FULL TEXT »

A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy

E van Hoffen et al., “A Specific Mixture of Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides Induces a Beneficial Immunoglobulin Profile in Infants at High Risk for Allergy.,” Allergy 64, no. 3 (March 2009): 484–87, doi:10.1111/j.1398-9995.2008.01765.x. FULL TEXT »

Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers

Jelena Vulevic et al., “Modulation of the Fecal Microflora Profile and Immune Function by a Novel Trans-Galactooligosaccharide Mixture (B-GOS) in Healthy Elderly Volunteers.,” The American Journal of Clinical Nutrition 88, no. 5 (November 1, 2008): 1438–46, doi:10.3945/ajcn.2008.26242. FULL TEXT »

Supplementation with galacto-oligosaccharides increases the percentage of NK cells and reduces colitis severity in Smad3-deficient mice.

Anita Gopalakrishnan et al., “Supplementation with Galacto-Oligosaccharides Increases the Percentage of NK Cells and Reduces Colitis Severity in Smad3-Deficient Mice.,” The Journal of Nutrition 142, no. 7 (July 2012): 1336–42, doi:10.3945/jn.111.154732. FULL TEXT »

Dietary oligofructose and inulin modulate immune functions in mice.

K.A Kelly-Quagliana, P.D Nelson, and R.K Buddington, “Dietary Oligofructose and Inulin Modulate Immune Functions in Mice,” Nutrition Research 23, no. 2 (February 2003): 257–67, doi:10.1016/S0271-5317(02)00516-X. ABSTRACT »

Isomalto-oligosaccharides polarize Th1-like responses in intestinal and systemic immunity in mice.

Hiroyuki Mizubuchi et al., “Isomalto-Oligosaccharides Polarize Th1-like Responses in Intestinal and Systemic Immunity in Mice.,” The Journal of Nutrition 135, no. 12 (December 2005): 2857–61. FULL TEXT »

Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactismodulates intestinal immune functions in rats

Monika Roller, Gerhard Rechkemmer, and Bernhard Watzl, “Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus Rhamnosus and Bifidobacterium Lactis Modulates Intestinal Immune Functions in Rats.,” The Journal of Nutrition 134, no. 1 (January 2004): 153–56. FULL TEXT »

A potential role for CD25+ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

Bastiaan Schouten et al., “A Potential Role for CD25+ Regulatory T-Cells in the Protection against Casein Allergy by Dietary Non-Digestible Carbohydrates,” British Journal of Nutrition 107, no. 01 (June 23, 2011): 96–105, doi:10.1017/S0007114511002637. FULL TEXT »

Oligosaccharide-induced whey-specific CD25(+) regulatory T-cells are involved in the suppression of cow milk allergy in mice

Bastiaan Schouten et al., “Oligosaccharide-Induced Whey-Specific CD25(+) Regulatory T-Cells Are Involved in the Suppression of Cow Milk Allergy in Mice.,” The Journal of Nutrition 140, no. 4 (April 1, 2010): 835–41, doi:10.3945/jn.109.116061. FULL TEXT »

Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice

Arjan P Vos et al., “Dietary Supplementation of Neutral and Acidic Oligosaccharides Enhances Th1-Dependent Vaccination Responses in Mice.,” Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology 18, no. 4 (June 2007): 304–12, doi:10.1111/j.1399-3038.2007.00515.x. ABSTRACT »

Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota

Patrice D Cani and Nathalie M Delzenne, “Interplay between Obesity and Associated Metabolic Disorders: New Insights into the Gut Microbiota.,” Current Opinion in Pharmacology 9, no. 6 (December 2009): 737–43, doi:10.1016/j.coph.2009.06.016. FULL TEXT »

Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?

Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease?,” Genes & Nutrition 6, no. 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1. ABSTRACT »

Gut microbiota and metabolic disorders: how prebiotic can work?

Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work?,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047. FULL TEXT »

The inflammatory status of old age can be nurtured from the intestinal environment.

Yves Guigoz, Joël Doré, and Eduardo J Schiffrin, “The Inflammatory Status of Old Age Can Be Nurtured from the Intestinal Environment.,” Current Opinion in Clinical Nutrition and Metabolic Care 11, no. 1 (January 2008): 13–20, doi:10.1097/MCO.0b013e3282f2bfdf. ABSTRACT »

Prebiotics

Thea Scantlebury Manning and Glenn R Gibson, “Microbial-Gut Interactions in Health and Disease. Prebiotics.,” Best Practice & Research. Clinical Gastroenterology 18, no. 2 (April 2004): 287–98, doi:10.1016/j.bpg.2003.10.008. ABSTRACT »

Hypothesis: Bacteria Control Host Appetites

Vic Norris, Franck Molina, and Andrew T Gewirtz, “Hypothesis: Bacteria Control Host Appetites.,” Journal of Bacteriology 195, no. 3 (February 2013): 411–16, doi:10.1128/JB.01384-12. FULL TEXT »

Dietary modulation of the human colonic microbiota: updating the concept of prebiotics

G R Gibson and M B Roberfroid, “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics.,” The Journal of Nutrition 125, no. 6 (July 1995): 1401–12. FULL TEXT »

Dietary fiber, Inulin, and oligofructose: A review comparing their physiological effects

M Roberfroid, “Dietary Fiber, Inulin, and Oligofructose: A Review Comparing Their Physiological Effects.,” Critical Reviews in Food Science and Nutrition 33, no. 2 (January 1993): 103–48, doi:10.1080/10408399309527616. ABSTRACT »

Prebiotic effects: metabolic and health benefits

Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363. FULL TEXT »

Nondigestible oligo-and polysaccharides (Dietary Fiber): their physiology and role in human health and food

B.C. Tungland and D. Meyer, “Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food,” Comprehensive Reviews in Food Science and Food Safety 1, no. 3 (October 2002): 90–109, doi:10.1111/j.1541-4337.2002.tb00009.x. FULL TEXT »

Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers

F Brighenti et al., “Effect of Consumption of a Ready-to-Eat Breakfast Cereal Containing Inulin on the Intestinal Milieu and Blood Lipids in Healthy Male Volunteers.,” European Journal of Clinical Nutrition 53, no. 9 (September 1999): 726–33. FULL TEXT »

Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men

H L Chen et al., “Effects of Isomalto-Oligosaccharides on Bowel Functions and Indicators of Nutritional Status in Constipated Elderly Men.,” Journal of the American College of Nutrition 20, no. 1 (February 2001): 44–49. ABSTRACT »

Yacon syrup: Beneficial effects on obesity and insulin resistance in humans

Susana Genta et al., “Yacon Syrup: Beneficial Effects on Obesity and Insulin Resistance in Humans,” Clinical Nutrition 28, no. 2 (2009): 182–87, doi:10.1016/j.clnu.2009.01.013.” ABSTRACT »

Effect of Prebiotic Fiber-Induced Changes in Gut Microbiota on Adiposity in Obese and Overweight Children

Alissa Nicolucci, Megan Hume, and Raylene Reimer, “Effect of Prebiotic Fiber-Induced Changes in Gut Microbiota on Adiposity in Obese and Overweight Children,” The FASEB Journal 29, no. 1 Supplement (April 1, 2015). ABSTRACT »

Use of isomalto-oligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients

Hsueh-Fang Wang et al., “Use of Isomalto-Oligosaccharide in the Treatment of Lipid Profiles and Constipation in Hemodialysis Patients,” Journal of Renal Nutrition 11, no. 2 (April 4, 2001): 73–79, doi:10.1016/S1051-2276(01)92591-9. ABSTRACT »

Long-term supplementation of isomalto-oligosaccharides improved colonic microflora profile, bowel function, and blood cholesterol levels in constipated elderly people—A placebo-controlled, diet-controlled trial

Chi-Hua Yen et al., “Long-Term Supplementation of Isomalto-Oligosaccharides Improved Colonic Microflora Profile, Bowel Function, and Blood Cholesterol Levels in Constipated Elderly people—A Placebo-Controlled, Diet-Controlled Trial,” Nutrition 27, no. 4 (April 4, 2011): 445–50, doi:10.1016/j.nut.2010.05.012. ABSTRACT »

Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?

Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease?,” Genes & Nutrition 6, no. 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1. ABSTRACT »

Gut microbiota and metabolic disorders: how prebiotic can work?

Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work?,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047. FULL TEXT »

Microbial-gut interactions in health and disease. Prebiotics.

Thea Scantlebury Manning and Glenn R Gibson, “Microbial-Gut Interactions in Health and Disease. Prebiotics.,” Best Practice & Research. Clinical Gastroenterology 18, no. 2 (April 2004): 287–98, doi:10.1016/j.bpg.2003.10.008. ABSTRACT »

Hypothesis: Bacteria Control Host Appetites

Vic Norris, Franck Molina, and Andrew T Gewirtz, “Hypothesis: Bacteria Control Host Appetites.,” Journal of Bacteriology 195, no. 3 (February 2013): 411–16, doi:10.1128/JB.01384-12. FULL TEXT »

Dietary modulation of the human colonic microbiota: Introducing the Concept of Prebiotics

G R Gibson and M B Roberfroid, “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics.,” The Journal of Nutrition 125, no. 6 (July 1995): 1401–12. FULL TEXT »

Dietary fiber, Inulin, and oligofructose: A review comparing their physiological effects

M Roberfroid, “Dietary Fiber, Inulin, and Oligofructose: A Review Comparing Their Physiological Effects.,” Critical Reviews in Food Science and Nutrition 33, no. 2 (January 1993): 103–48, doi:10.1080/10408399309527616. ABSTRACT »

Prebiotic effects: metabolic and health benefits

Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363. FULL TEXT »

Nondigestible oligo-and polysaccharides (Dietary Fiber): their physiology and role in human health and food

B.C. Tungland and D. Meyer, “Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food,” Comprehensive Reviews in Food Science and Food Safety 1, no. 3 (October 2002): 90–109, doi:10.1111/j.1541-4337.2002.tb00009.x. FULL TEXT »

Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria?

Steve M D'Souza, Kevin Houston, Lauren Keenan, Byung Soo Yoo, Parth J Parekh, David A Johnson, "Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease: A paradigm shift from acid to bacteria,?" World J Gastroenterol. 2021 May 14;27(18):2054-2072. doi: 10.3748/wjg.v27.i18.2054 ABSTRACT »

Microbiome and Gastroesophageal Disease: Pathogenesis and Implications for Therapy

How to cite this article: D’Souza SM, Cundra LB, Yoo BS, Parekh PJ, Johnson DA. Microbiome and Gastroesophageal Disease: Pathogenesis and Implications for Therapy. Ann Clin Gastroenterol Hepatol. 2020; 4: 020-033. DOI: 10.29328/journal.acgh.1001018 ABSTRACT »